Bioactive Small Molecules

5-(4-ethylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one

10058, 10058-F4, 1RH, MI-3

10058-F4 (click to show)
10058-F4 (click to hide)
Title:
Improved low molecular weight Myc-Max inhibitors
Reference:
Mol Cancer Ther. 2007 Sep;6(9):2399-408.
Authors:
Wang H, Hammoudeh DI, Follis AV, Reese BE, Lazo JS, Metallo SJ, Prochownik EV.
Compounds:
10058-F4 (5404711), 1RH (5404711), 12RH (5148440), 22RH {not in our database}, 27RH (5170837), 28RH (5200824), 1RH-S-Me {not in our database}, 1RH-NCN-1 {not in our database}, #015 (6838015), #474 (6123474), #764 (6863764), 12RH-NCN-1 {not in our database}, 28RH-NCN-1 {not in our database}
10058-F4 (click to show)
10058-F4 (click to hide)
Title:
Low molecular weight inhibitors of Myc-Max interaction and function
Reference:
Oncogene 2003 Sep 18;22(40):6151-9
Authors:
Xiaoying Yin, Christine Giap, John S Lazo, Edward V Prochownik
Compounds:
10009-G9 (5561686), 10050-C10 (5154282), 10058-F4 (5404711), 10074-A4 (5236925)
10058-F4 (click to show)
10058-F4 (click to hide)
Title:
Discovery of Novel Myc-Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model
Reference:
J. Med. Chem., 2009 Mar 12;52(5):1247-50
Authors:
Gabriela Mustata, Ariele Viacava Follis, Dalia I. Hammoudeh, Steven J. Metallo, Huabo Wang, Edward V. Prochownik, John S. Lazo and Ivet Bahar
Compounds:
10058-F4 (5404711), 12RH (5148440), 27RH (5170837), 28RH (5200824), #474 (6123474), #764 (6863764), Compound 2 (5140069), Compound 3 (6569963), Compound 4 (6525237), Compound 5 (5360134), Compound 6 (6370870), Compound 7 (5928105), Compound 8 (5149518), Compound 9 (7116536), Compound 10 (5248624)
MI-3 (click to show)
MI-3 (click to hide)
Title:
Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin
Reference:
The EMBO Journal 2006 Jul 26;25(14):3298-309.
Authors:
Lina Williamson, Natalia A Raess, Reto Caldelari, Anthony Zakher, Alain de Bruin, Horst Posthaus, Reinhard Bolli, Thomas Hunziker, Maja M Suter and Eliane J M�ller
Compounds:
MI-1 (5521700), MI-3 (5404711)
10058-F4 (click to show)
10058-F4 (click to hide)
Title:
Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc
Reference:
Journal of the American Chemical Society 2009 Jun 3;131(21):7390-401
Authors:
Dalia I. Hammoudeh, Ariele Viacava Follis, Edward V. Prochownik, Steven J. Metallo
Compounds:
10009-G9 (5561686), 10050-C10 (5154282), 10058-F4 (5404711), 10074-A4 (5236925), 10031-B8 (5521700), 10075-G5 (5313125), 10074-G5 (5241491)
10058 (click to show)
10058 (click to hide)
Title:
Direct observation of individual endogenous protein complexes in situ by proximity ligation
Reference:
Nature Methods, 2006 Dec;3(12):995-1000
Authors:
Ola Soederberg, Mats Gullberg, Malin Jarvius, Karin Ridderstrale, Karl-Johan Leuchowius, Jonas Jarvius, Kenneth Wester, Per Hydbring, Fuad Bahram, Lars-Gunnar Larsson & Ulf Landegren
Compounds:
10058 (5404711), 10074 (5236925)