Bioactive Small Molecules

33M20, BLT-1, BLT1, HDL

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Role of macrophage activation in the lipid metabolism of postprandial triacylglycerol-rich lipoproteins

Reference:

Experimental Biology and Medicine, 2013 Jan;238(1):98-110

Authors:

Mariarosaria Napolitano, Simona Sennato, Kathleen M Botham, Federico Bordi and Elena Bravo

Compounds:

BLT-1 (5234221), BLT-4 (5109586)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis

Reference:

J. Lipid Res. 2013 Feb;54(2):365-78.

Authors:

Lai WA, Yeh YT, Lee MT, Wu LS, Ke FC, Hwang JJ.

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

The role of NF-кB in SAA-induced peroxisome proliferator-activated receptor g activation

Reference:

Atherosclerosis, 2013 Mar;227(1):72-8

Authors:

Hongzhe Li, Shu Qin Ooi, Chew-Kiat Heng

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Biomimetic, synthetic HDL nanostructures for lymphoma

Reference:

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2511-6

Authors:

Yang S, Damiano MG, Zhang H, Tripathy S, Luthi AJ, Rink JS, Ugolkov AV, Singh AT, Dave SS, Gordon LI, Thaxton CS.

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI

Reference:

PNAS November 26, 2002 vol. 99 no. 24 15422-15427

Authors:

Thomas J. F. Nieland, Marsha Penman, Limor Dori, Monty Krieger, and Tomas Kirchhausen

Compounds:

BLT-1 (5234221), BLT-2 (5234225), BLT-3 (5106931), BLT-4 (5109586), BLT-5 (5117098)

33M20 (click to show)

33M20 (click to hide)

Title:

Small molecule developmental screens reveal the logic and timing of vertebrate development

Reference:

PNAS November 21, 2000 vol. 97 no. 24 12965-12969

Authors:

Randall T. Peterson, Brian A. Link, John E. Dowling, and Stuart L. Schreiber

Compounds:

32N8 (5175083), 33M20 (5234221), 32N5 (5150905), 31J6 (5266239), 32P6 (5243294), 31B4 (5101231), 33N14 (5251609), 31N3 (5138859)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection

Reference:

Cell Host & Microbe, 2008 Sep 11;4(3):271-82

Authors:

Cristina D. Rodrigues,Michael Hannus,Miguel Prudencio,Cecilie Martin,Ligia A. Goncalves,Silvia Portugal,Sabrina Epiphanio,Akin Akinc,Philipp Hadwiger,Kerstin Jahn-Hofmann,Ingo R�hl,Geert-Jan van Gemert,Jean-Francois Franetich,Adrian J.F. Luty,Robert Saue

Compounds:

BLT-1 (5234221), BLT-2 (5234225), BLT-4 (5109586), BLT-1sc (5152562)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages

Reference:

Cardiovasc Res. 2009 Aug 1;83(3):457-64. Epub 2009 Apr 17.

Authors:

Kim Bujold, David Rhainds, Christian Jossart, Maria Febbraio, Sylvie Marleau and Huy Ong

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

LDLs stimulate p38 mitogen-activated kinases and wound healing through the class B type 1 scavenger receptor independently of Ras and PI3 kinase

Reference:

Journal of Lipid Research, 2009 Jan;50(1):81-9

Authors:

Bulat N, Waeber G, Widmann C.

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Lycopene Absorption in Human Intestinal Cells and in Mice Involves Scavenger Receptor Class B Type I but Not Niemann-Pick C1-Like 1

Reference:

J. Nutr. 2008 Aug;138(8):1432-6.

Authors:

Myriam Moussa, Jean-Francois Landrier, Emmanuelle Reboul, Odette Ghiringhelli, Christine Comera, Xavier Collet, Kati Frohlich, Volker Bohm and Patrick Borel

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development

Reference:

Toxicol Lett. 2007 Dec 10;175(1-3), 1-7

Authors:

Raldua D, Babin PJ

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.

Reference:

Atherosclerosis. 2013 Jun;228(2):353-61. doi: 10.1016/j.atherosclerosis.2013.03.005. Epub 2013 Mar 20.

Authors:

Aharoni S, Aviram M, Fuhrman B.

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans.

Reference:

J Nutr. 2013 Apr;143(4):448-56. doi: 10.3945/jn.112.172734.

Authors:

Borel P, Lietz G, Goncalves A, Szabo de Edelenyi F, Lecompte S, Curtis P, Goumidi L, Caslake MJ, Miles EA, Packard C, Calder PC, Mathers JC, Minihane AM, Tourniaire F, Kesse-Guyot E, Galan P, Hercberg S, Breidenassel C, González Gross M, Moussa M, Meirhae

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx

Reference:

Biochemical and Biophysical Research Communications, Volume 391, Issue 1, 1 January 2010, Pages 523-528, ISSN 0006-291X, DOI: 10.1016/j.bbrc.2009.11.091.

Authors:

Anna Gantman, Bianca Fuhrman, Michael Aviram, Tony Hayek

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Small Discoidal Pre-beta 1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

Reference:

Biochemistry 2009 48 (46), 11067-11074

Authors:

Elda Favari, Laura Calabresi, Maria Pia Adorni, Wendy Jessup, Sara Simonelli, Guido Franceschini, Franco Bernini

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity

Reference:

Biochemistry, 2008 Jan 8;47(1):460-72. Epub 2007 Dec 8.

Authors:

Thomas J. F. Nieland, Jared T. Shaw, Firoz A. Jaipuri, Jay L. Duffner, Angela N. Koehler, Sotirios Banakos, Vassilis I. Zannis, Tomas Kirchhausen, and Monty Krieger

Compounds:

Compound 1 (5136875), Compound 2 (5136871), Compound 3 (5234224), Compound 4 (5234954), Compound 5 (5554654), Compound 6 (8016115), Compound 7 (8016113), Compound 8 (5153618), Compound 9 (5136957), BLT-1 (5234221), BLT-2 (5234225), BLT-3 (5106931), BLT-4 (5109586), BLT-5 (5117098), BLT-1sc (5152562)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Sensing of Dietary Lipids by Enterocytes: A New Role for SR-BI/CLA-1

Reference:

PLoS ONE, 2009;4(1):e4278. Epub 2009 Jan 26.

Authors:

Beaslas, Olivier ; Cueille, Carine ; Delers, Francois ; Chateau, Danielle ; Chambaz, Jean ; Rousset, Monique ; Carriere, Veronique

Compounds:

BLT-1 (5234221)

BLT-1 (click to show)

BLT-1 (click to hide)

Title:

Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17[beta]-estradiol fatty acyl esters

Reference:

The Journal of Steroid Biochemistry and Molecular Biology, 2009 Aug;116(1-2):44-9. Epub 2009 May 3.

Authors:

Robert M. Badeau, Jari Metso, Kristiina Wahala, Matti J. Tikkanen, Matti Jauhiainen

Compounds:

BLT-1 (5234221)

BLT1 (click to show)

BLT1 (click to hide)

Title:

Intestinal Scavenger Receptors Are Involved in Vitamin K1 Absorption

Reference:

J Biol Chem. 2014 Oct 31;289(44):30743-52. doi: 10.1074/jbc.M114.587659. Epub 2014 Sep 15.

Authors:

Goncalves A, Margier M, Roi S, Collet X, Niot I, Goupy P, Caris-Veyrat C, Reboul E

Compounds:

BLT1 (5234221)

HDL (click to show)

HDL (click to hide)

Title:

Imaging the cytosolic drug delivery mechanism of HDL-like nanoparticles.

Reference:

Pharm Res. 2014 Jun;31(6):1438-49. Epub 2013 Apr 27

Authors:

Lin Q, Chen J, Ng KK, Cao W, Zhang Z, Zheng G.

Compounds:

HDL (5234221)