Bioactive Small Molecules

BLT-4, INF 271, INF271

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Role of macrophage activation in the lipid metabolism of postprandial triacylglycerol-rich lipoproteins

Reference:

Experimental Biology and Medicine, 2013 Jan;238(1):98-110

Authors:

Mariarosaria Napolitano, Simona Sennato, Kathleen M Botham, Federico Bordi and Elena Bravo

Compounds:

BLT-1 (5234221), BLT-4 (5109586)

INF 271 (click to show)

INF 271 (click to hide)

Title:

Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus

Reference:

Antimicrobial Agents and Chemotherapy 1999 Oct;43(10):2404-8

Authors:

Penelope N. Markham, Eric Westhaus, Katya Klyachko, Michael E. Johnson, and Alex A. Neyfakh

Compounds:

INF 55 (5107950), INF 240 (5187143), INF 271 (5109586), INF 277 (5213684), INF 392 (5241292)

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI

Reference:

PNAS November 26, 2002 vol. 99 no. 24 15422-15427

Authors:

Thomas J. F. Nieland, Marsha Penman, Limor Dori, Monty Krieger, and Tomas Kirchhausen

Compounds:

BLT-1 (5234221), BLT-2 (5234225), BLT-3 (5106931), BLT-4 (5109586), BLT-5 (5117098)

INF271 (click to show)

INF271 (click to hide)

Title:

Conjugating Berberine to a Multidrug Resistance Pump Inhibitor Creates an Effective Antimicrobial

Reference:

ACS Chem Biol. 2006 Oct 24;1(9):594-600.

Authors:

Ball, Anthony R., Casadei, Gabriele, Samosorn, Siritron, Bremner, John B., Ausubel, Frederick M., Moy, Terence I. and Lewis, Kim

Compounds:

INF55 (5107950), INF271 (5109586)

INF271 (click to show)

INF271 (click to hide)

Title:

Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation

Reference:

Antimicrobial Agents and Chemotherapy, 2008 Sep;52(9):3202-9

Authors:

George P Tegos, Kayo Masago, Fatima Aziz, Andrew Higginbotham, Frank R Stermitz, and Michael R. Hamblin

Compounds:

INF271 (5109586)

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection

Reference:

Cell Host & Microbe, 2008 Sep 11;4(3):271-82

Authors:

Cristina D. Rodrigues,Michael Hannus,Miguel Prudencio,Cecilie Martin,Ligia A. Goncalves,Silvia Portugal,Sabrina Epiphanio,Akin Akinc,Philipp Hadwiger,Kerstin Jahn-Hofmann,Ingo R�hl,Geert-Jan van Gemert,Jean-Francois Franetich,Adrian J.F. Luty,Robert Saue

Compounds:

BLT-1 (5234221), BLT-2 (5234225), BLT-4 (5109586), BLT-1sc (5152562)

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide

Reference:

Journal of Lipid Research 2004 Jul;45(7):1256-65. Epub 2004 Apr 21

Authors:

Thomas J. F. Nieland, Angeliki Chroni, Michael L. Fitzgerald, Zoltan Maliga, Vassilis I. Zannis, Tomas Kirchhausen, and Monty Krieger

Compounds:

BLT-4 (5109586)

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains

Reference:

PLoS Pathogens, 2009 Feb;5(2)

Authors:

Dreux, Marlene ; Dao Thi, Viet Loan ; Fresquet, Judith ; Guerin, Maryse ; Julia, Zelie ; Verney, Geraldine ; Durantel, David ; Zoulim, Fabien ; Lavillette, Dimitri ; Cosset, Francois-Loic ; Bartosch, Birke

Compounds:

BLT-4 (5109586)

BLT-4 (click to show)

BLT-4 (click to hide)

Title:

Identification of the Molecular Target of Small Molecule Inhibitors of HDL Receptor SR-BI Activity

Reference:

Biochemistry, 2008 Jan 8;47(1):460-72. Epub 2007 Dec 8.

Authors:

Thomas J. F. Nieland, Jared T. Shaw, Firoz A. Jaipuri, Jay L. Duffner, Angela N. Koehler, Sotirios Banakos, Vassilis I. Zannis, Tomas Kirchhausen, and Monty Krieger

Compounds:

Compound 1 (5136875), Compound 2 (5136871), Compound 3 (5234224), Compound 4 (5234954), Compound 5 (5554654), Compound 6 (8016115), Compound 7 (8016113), Compound 8 (5153618), Compound 9 (5136957), BLT-1 (5234221), BLT-2 (5234225), BLT-3 (5106931), BLT-4 (5109586), BLT-5 (5117098), BLT-1sc (5152562)