Bioactive Small Molecules

Fragment 1

Fragment 1 (click to show)

Fragment 1 (click to hide)

Title:

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Reference:

J Med Chem. 2016 Jan 14;59(1):374-87. Epub 2015 Dec 23.

Authors:

Rasina D, Otikovs M, Leitans J, Recacha R, Borysov OV, Kanepe-Lapsa I, Domraceva I, Pantelejevs T, Tars K, Blackman MJ, Jaudzems K, Jirgensons A.

Compounds:

Fragment 1 (9127016), Fragment 2 (7948757)