Bioactive Small Molecules

Compound 68

Compound 68 (click to show)

Compound 68 (click to hide)

Title:

Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson’s disease cell and mouse models

Reference:

Hum Mol Genet. 2014 Dec 1;23(23):6212-22. doi: 10.1093/hmg/ddu341. Epub 2014 Jul 3.

Authors:

Li T, Yang D, Zhong S, Thomas JM, Xue F, Liu J, Kong L, Voulalas P, Hassan HE, Park JS, MacKerell AD Jr, Smith WW

Compounds:

Compound 68 (9108605), Compound 70 (9119202)

Compound 68 (click to show)

Compound 68 (click to hide)

Title:

A Novel GTP-Binding Inhibitor, FX2149, Attenuates LRRK2 Toxicity in Parkinson’s Disease Models

Reference:

PLoS One. 2015 Mar 27;10(3):e0122461. doi: 10.1371/journal.pone.0122461. eCollection 2015.

Authors:

Li T, He X, Thomas JM, Yang D, Zhong S, Xue F, Smith WW

Compounds:

Compound 68 (9108605)

Compound 68 (click to show)

Compound 68 (click to hide)

Title:

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-alpha Release in Human Lymphoblasts

Reference:

Cells . 2021 Feb 23;10(2):480. doi: 10.3390/cells10020480.

Authors:

Tianxia Li 1 2, Bo Ning, Lingbo Kong, Bingling Dai, Xiaofei He, Joseph M Thomas, Akira Sawa, Christopher A Ross, Wanli W Smith

Compounds:

Compound 68 (9108605)