Bioactive Small Molecules

N-(3-chloro-4-fluorophenyl)-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine dihydrochloride

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Title:
An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis
Reference:
Eur J Med Chem. 2015 Sep 9;103:539-550. doi: 10.1016/j.ejmech.2015.09.008. [Epub ahead of print]
Authors:
Teo T, Yang Y, Yu M, Basnet SK, Gillam T, Hou J, Schmid RM, Kumarasiri M, Diab S, Albrecht H, Sykes MJ, Wang S
Compounds:
1 (7980544), 2 (6234042), 3 (6991884)