Bioactive Small Molecules

5-methyl- N-(4-nitrophenyl)thiophene-2-carboxamide, 7947882

5-methyl- N-(4-nitrophenyl)thiophene-2-carboxamide (click to show)

5-methyl- N-(4-nitrophenyl)thiophene-2-carboxamide (click to hide)

Title:

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Reference:

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

Authors:

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR

Compounds:

7947882 (7947882), 7904688 (7904688), 5-methyl- N-(4-nitrophenyl)thiophene-2-carboxamide (7947882), 3-phenyl-N-[(4-piperidin-1-ylphenyl)carbamothioyl] propanamide (7904688)

7947882 (click to show)

7947882 (click to hide)

Title:

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

Reference:

Sci Rep. 2018 Feb 16;8(1):3187. doi: 10.1038/s41598-018-21614-4.

Authors:

Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanova J, Szadocka S, Huszar S, Palcekova Z, Manfredi M, Gosetti F, Lelievre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR

Compounds:

7904688 (7904688), 7947882 (7947882)