Bioactive
Small Molecules
C2BA-8
C2BA-8 (click to show)
C2BA-8 (click to hide)
Title:
Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to In Vivo Biological Activity
Reference:
Mol Pharmacol. 2007 Sep;72(3):572-81
Authors:
Geraldine Lemaire, Cindy Benod, Virginie Nahoum, Arnaud Pillon, Anne-Marie Boussioux, Jean-Francois Guichou, Guy Subra, Jean-Marc Pascussi, William Bourguet, Alain Chavanieu, and Patrick Balaguer
Compounds:
C2BA-4 (
7896130
), C2BA-5 (
7754300
), C2BA-6 (
7931751
), C2BA-7 (
7960156
), C2BA-8 (
7902591
), C2BA-10 (
7906112
), C2BA-13 (
7988475
), C2BA-248 (
7976441
), C2BA-251 (
7976441
)
![2-({4-benzyl-5-[(3,4-dimethylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}thio)-N-(3-chlorophenyl)acetamide](/img/SC/790/7902591.jpeg "2-({4-benzyl-5-[(3,4-dimethylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}thio)-N-(3-chlorophenyl)acetamide")