Bioactive
Small Molecules
SKP2E3LI-L6
SKP2E3LI-L6 (click to show)
SKP2E3LI-L6 (click to hide)
Title:
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.
Reference:
Endocrinology. 2013 Nov;154(11):4030-45. Epub 2013 Sep 13.
Authors:
Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI.
Compounds:
SKP2E3LI-C5 (
6719837
), SKP2E3LI-C2 (
6544607
), SKP2E3LI-C16 (
6744881
), SKP2E3LI-C1 (
6281766
), SKP2E3LI-L6 (
7839058
)
![4-bromo-N-[4-hydroxy-3-(1H-1,2,4-triazol-3-ylthio)-1-naphthyl]benzenesulfonamide](/img/SC/783/7839058.jpeg "4-bromo-N-[4-hydroxy-3-(1H-1,2,4-triazol-3-ylthio)-1-naphthyl]benzenesulfonamide")