Bioactive Small Molecules

DM-PIT-1

DM-PIT-1 (click to show)

DM-PIT-1 (click to hide)

Title:

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

Reference:

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. Epub 2010 Nov 1.

Authors:

Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A.

Compounds:

PIT-1 (5535396), DM-PIT-1 (7797459), PIT-1i-1 {not in our database}, PIT-1i-2 {not in our database}