Bioactive Small Molecules

DA5

DA5 (click to show)

DA5 (click to hide)

Title:

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Reference:

Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809. Epub 2012 Jan 17.

Authors:

Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE 3rd, Boshoff HI.

Compounds:

DA5 (7505073), DA8 (7878507)