Bioactive Small Molecules

CCG-4986

CCG-4986 (click to show)

CCG-4986 (click to hide)

Title:

Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay

Reference:

Mol Pharmacol, 2007 Jan;71(1):169-75

Authors:

David L. Roman, Jeffery N. Talbot, Rebecca A. Roof, Roger K. Sunahara, John R. Traynor, and Richard R. Neubig

Compounds:

CCG-4986 (7003154)

CCG-4986 (click to show)

CCG-4986 (click to hide)

Title:

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face

Reference:

Biochim Biophys Acta. 2007 Sep;1774(9):1213-20

Authors:

Adam J. Kimple, Francis S. Willard, Patrick M. Giguere, Christopher A. Johnston, Viorel Mocanu, David P. Siderovski

Compounds:

CCG-4986 (7003154)

CCG-4986 (click to show)

CCG-4986 (click to hide)

Title:

GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons

Reference:

Neuropharmacology. 2013 Sep;72:106-15.

Authors:

Zhang L, Kolaj M, Renaud LP.

Compounds:

CCG-4986 (7003154)

CCG-4986 (click to show)

CCG-4986 (click to hide)

Title:

Microfabricated Channel Array Electrophoresis for Characterization and Screening of Enzymes Using RGS-G Protein Interactions as a Model System

Reference:

Anal. Chem., 2008 Jul 1;80(13):5225-31. Epub 2008 May 9

Authors:

Jian Pei, John F. Dishinger, David L. Roman, Chetwana Rungwanitcha, Richard R. Neubig and Robert T. Kennedy

Compounds:

CCG-4986 (7003154)