Bioactive
Small Molecules
SID7975595
SID7975595 (click to show)
SID7975595 (click to hide)
Title:
Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)
Reference:
Bioorganic & Medicinal Chemistry, 2010 Jan 15;18(2):896-908. doi: 10.1016/j.bmc.2009.11.033. Epub 2009 Nov 20.
Authors:
Sharmila Sivendran, Victoria Jones, Dianqing Sun, Yi Wang, Anna E. Grzegorzewicz, Michael S. Scherman, Andrew D. Napper, J. Andrew McCammon, Richard E. Lee, Scott L. Diamond, Michael McNeil
Compounds:
SID7975595 (
6892686
), 77070 (
6904191
), 77071 (
7093044
), 77072 (
6665037
), 77073 (
6922675
), 77074 (
7077074
), 5-ethyl-5H-[1,2,4]triazino[5,6- b]indole-3-thiol (
5251353
)
![1-{3-[(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]propyl}-1,3-dihydro-2H-benzimidazol-2-one](/img/SC/689/6892686.jpeg "1-{3-[(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]propyl}-1,3-dihydro-2H-benzimidazol-2-one")