Bioactive
Small Molecules
SKP2E3LI-C16
SKP2E3LI-C16 (click to show)
SKP2E3LI-C16 (click to hide)
Title:
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.
Reference:
Endocrinology. 2013 Nov;154(11):4030-45. Epub 2013 Sep 13.
Authors:
Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI.
Compounds:
SKP2E3LI-C5 (
6719837
), SKP2E3LI-C2 (
6544607
), SKP2E3LI-C16 (
6744881
), SKP2E3LI-C1 (
6281766
), SKP2E3LI-L6 (
7839058
)
![[4-({3-[2-(4-chlorophenyl)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene}methyl)phenoxy]acetic acid](/img/SC/674/6744881.jpeg "[4-({3-[2-(4-chlorophenyl)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene}methyl)phenoxy]acetic acid")