Bioactive Small Molecules

C1, SKP2E3LI-C5

C1 (click to show)

C1 (click to hide)

Title:

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation

Reference:

Chem Biol. 2012 Dec 21;19(12):1515-24.

Authors:

Wu L, Grigoryan AV, Li Y, Hao B, Pagano M, Cardozo TJ.

Compounds:

C1 (6719837)

SKP2E3LI-C5 (click to show)

SKP2E3LI-C5 (click to hide)

Title:

Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.

Reference:

Endocrinology. 2013 Nov;154(11):4030-45. Epub 2013 Sep 13.

Authors:

Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI.

Compounds:

SKP2E3LI-C5 (6719837), SKP2E3LI-C2 (6544607), SKP2E3LI-C16 (6744881), SKP2E3LI-C1 (6281766), SKP2E3LI-L6 (7839058)