Bioactive
Small Molecules
AK-1
AK-1 (click to show)
AK-1 (click to hide)
Title:
Linking SIRT2 to Parkinsons Disease
Reference:
ACS Chemical Biology, 2007 Aug 17;2(8):529-32.
Authors:
Adam L. Garske, Brian C. Smith, and John M. Denu
Compounds:
B2 (
6133799
), AGK2 (
5857140
), AK-1 (
6642056
)
AK-1 (click to show)
AK-1 (click to hide)
Title:
Sirtuin 2 Inhibitors Rescue a-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
Reference:
Science 2007 Jul 27;317(5837):516-9
Authors:
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M. Altmann, Irina Kufareva, Katherine E. Strathearn, Allison M. Amore, Catherine B. Volk, Michele M. Maxwell, Jean-Christophe Rochet, Pamela J. McLean, Anne B. Young, Ruben Abagyan, Mel B. Feany, Bradley
Compounds:
AGK2 (
5857140
), AK-1 (
6642056
)
AK-1 (click to show)
AK-1 (click to hide)
Title:
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase
Reference:
ACS Chem Biol. 2011 Jun 17;6(6):540-6. doi: 10.1021/cb100376q. Epub 2011 Mar 9.
Authors:
David M. Taylor, Uma Balabadra, Zhongmin Xiang, Ben Woodman, Sarah Meade, Allison Amore, Michele M. Maxwell, Steven Reeves, Gillian P. Bates, Ruth Luthi-Carter, Philip A. S. Lowden, and Aleksey G. Kazantsev
Compounds:
6648610 (
6648610
), 6666243 (
6666243
), 6680310 (
6680310
), 6670011 (
6670011
), AK-7 (
6672313
), AK-1 (
6642056
), 5210809 (
5210809
)
AK-1 (click to show)
AK-1 (click to hide)
Title:
A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli
Reference:
ACS Chem Biol. 2012 Sep 21;7(9):1547-55. Epub 2012 Jun 22.
Authors:
Patricia L. Taylor, Laura Rossi, Gianfranco De Pascale, and Gerard D. Wright
Compounds:
C2-10-1 (
5346237
), C2-10-2 (
5921967
), 6680310 (
6671446
), 6670011 (
6670011
), AK-7 (
6672313
), AK-1 (
6642056
), 5210809 (
5914543
)
