Bioactive Small Molecules

5-{[1-(4-bromophenyl)-1H-pyrrol-2-yl]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione

UPRM8

UPRM8 (click to show)
UPRM8 (click to hide)
Title:
A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity
Reference:
Chembiochem. 2016 May 3;17(9):843-51. Epub 2016 Mar 7.
Authors:
Jansen G, Golizeh M, Martel-Lorion C, Dejgaard K, Shiao TC, Mancuso J, Tsantrizos YS, Roy R, Sebag M, Sleno L, Thomas DY, Waller DD
Compounds:
UPRM8 (6314300)