Bioactive
Small Molecules
SKP2E3LI-C1
SKP2E3LI-C1 (click to show)
SKP2E3LI-C1 (click to hide)
Title:
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.
Reference:
Endocrinology. 2013 Nov;154(11):4030-45. Epub 2013 Sep 13.
Authors:
Pavlides SC, Huang KT, Reid DA, Wu L, Blank SV, Mittal K, Guo L, Rothenberg E, Rueda B, Cardozo T, Gold LI.
Compounds:
SKP2E3LI-C5 (
6719837
), SKP2E3LI-C2 (
6544607
), SKP2E3LI-C16 (
6744881
), SKP2E3LI-C1 (
6281766
), SKP2E3LI-L6 (
7839058
)
![4-[(5-imino-2-isopropyl-7-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6(7H)-ylidene)methyl]-2-methoxyphenyl 4-chlorobenzoate](/img/SC/628/6281766.jpeg "4-[(5-imino-2-isopropyl-7-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6(7H)-ylidene)methyl]-2-methoxyphenyl 4-chlorobenzoate")