Bioactive Small Molecules

3,5-dibromo-N′-([2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl] methylene)-4-hydroxybenzohydrazide, Kinesore

3,5-dibromo-N′-([2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl] methylene)-4-hydroxybenzohydrazide (click to show)

3,5-dibromo-N′-([2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl] methylene)-4-hydroxybenzohydrazide (click to hide)

Title:

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

Reference:

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743. doi: 10.1073/pnas.1715115115. Epub 2017 Dec 11.

Authors:

Randall TS, Yip YY, Wallock-Richards DJ, Pfisterer K, Sanger A, Ficek W, Steiner RA, Beavil AJ, Parsons M, Dodding MP

Compounds:

Kinesore (6233307), 3,5-dibromo-N′-([2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl] methylene)-4-hydroxybenzohydrazide (6233307)