Bioactive Small Molecules

2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

Compound 102, HC-030031, HC030031

HC-030031 (click to hide)

Title:: TRPA1 in Bradykinin-induced Mechano-hypersensitivity of Vagal C Fibers in Guinea Pig Esophagus
Reference:: Am J Physiol Gastrointest Liver Physiol 2009 Feb;296(2):G255-65
Authors:: Shaoyong Yu and Ann Ouyang
Compounds:: HC-030031 (6106799)

Title:: TRPA1 in Mast Cell Activation-induced Long-lasting Mechanical Hypersensitivity of Vagal Afferent C fibers in Guinea Pig Esophagus.
Reference:: Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G34-42. Epub 2009 May 7.
Authors:: Shaoyong Yu, Guofeng Gao, Blaise Z Peterson, and Ann Ouyang
Compounds:: HC-030031 (6106799)

Title:: HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
Reference:: Molecular Pain 2008 Oct 27;4:48
Authors:: Samer R Eid , Eric D Crown , Eric L Moore , Hongyu A Liang , Kar-Chan Choong , Shelley Dima , Darrell A Henze , Stefanie A Kane and Mark O Urban
Compounds:: HC-030031 (6106799)

Title:: The Nociceptor Ion Channel TRPA1 is Potentiated and Inactivated by Permeating Calcium Ions
Reference:: J. Biol. Chem., 2008 Nov 21;283(47):32691-703.
Authors:: Yuanyuan Wang, Rui B. Chang, Hang N. Waters, David D. McKemy, and Emily R. Liman
Compounds:: HC-030031 (6106799)

Title:: TRPA1 Mediates Formalin-induced Pain
Reference:: PNAS, 104 (33): 13525-13530, 2007
Authors:: CR McNamara, J Mandel-Brehm, DM Bautista, J Slemens, KL Deranian, M Zhao, NJ Hayward, JA Chong, D Julius, MM Moran, and CM Fanger
Compounds:: HC-030031 (6106799)

Title:: Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene Bâ‚„-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1.
Reference:: FASEB J. 2013 Apr;27(4):1664-73. doi: 10.1096/fj.12-221218
Authors:: Fernandes ES, Vong CT, Quek S, Cheong J, Awal S, Gentry C, Aubdool AA, Liang L, Bodkin JV, Bevan S, Heads R, Brain SD.
Compounds:: HC-030031 (6106799)

Title:: Diallyl sulfides in garlic activate both TRPA1 and TRPV1
Reference:: Biochemical and Biophysical Research Communications, Volume 382, Issue 3, 8 May 2009, Pages 545-548, ISSN 0006-291X, DOI: 10.1016/j.bbrc.2009.03.066.
Authors:: Kanako Koizumi, Yusaku Iwasaki, Masataka Narukawa, Yuji Iitsuka, Tomomi Fukao, Taiichiro Seki, Toyohiko Ariga, Tatsuo Watanabe
Compounds:: HC030031 (6106799)

Title:: Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents
Reference:: Journal of Medicinal Chemistry 2010 Jul 22;53(14):5085-107.
Authors:: Pier Giovanni Baraldi, Delia Preti, Serena Materazzi, Pierangelo Geppetti
Compounds:: Compound 102 (6106799), Compound 104 (5861528)

Title:: Miogadial and miogatrial with [alpha],[beta]-unsaturated 1,4-dialdehyde moieties--Novel and potent TRPA1 agonists
Reference:: Life Sciences, 2009 Jul 3;85(1-2):60-9. Epub 2009 May 3.
Authors:: Yusaku Iwasaki, Manabu Tanabe, Yuko Kayama, Masako Abe, Makiko Kashio, Kanako Koizumi, Yukiko Okumura, Yasujiro Morimitsu, Makoto Tominaga, Yoshio Ozawa, Tatsuo Watanabe
Compounds:: HC-030031 (6106799)

Title:: Structureâˆ’Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard
Reference:: J Nat Prod. 2015 Aug 28;78(8):1937-41. Epub 2015 Aug 11.
Authors:: Terada Y, Masuda H, Watanabe T.
Compounds:: HC-030031 (6106799)

Title:: Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.
Reference:: J Nat Prod. 2014 Aug 22;77(8):1831-8.
Authors:: Terada Y, Kitajima M, Taguchi F, Takayama H, Horie S, Watanabe T.
Compounds:: HC-030031 (6106799)