Bioactive Small Molecules

Compound 1, Compound 4

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis

Reference:

J. Med. Chem. 2007 Nov 15;50(23):5735-42

Authors:

Min Huang, Sheng-Xue Xie, Ze-Qiang Ma, Qing-Qing Huang, Fa-Jun Nan, and Qi-Zhuang Ye

Compounds:

Compound 1 (6025190), Compound 3 (5730590)

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Structural analysis of metalloform-selective inhibition of methionine aminopeptidase

Reference:

Acta Cryst. 2006 Apr; 62(Pt 4):425-32

Authors:

S.-X. Xie, W.-J. Huang, Z.-Q. Ma, M. Huang, R. P. Hanzlik and Q.-Z. Ye

Compounds:

Compound 1 (6025190), Compound 2 (6009336), Compound 3 (6281056), Compound 4 (5659206)

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymes

Reference:

BMC Struct Biol. 2007 Dec 19;7:84.

Authors:

Ze-Qiang Ma, Sheng-Xue Xie, Qing-Qing Huang, Fa-Jun Nan, Thomas D Hurley, and Qi-Zhuang Ye

Compounds:

Compound 1 (6025190), Compound 2 (6009336), Compound 3 (6281056), Compound 6 (6108575), Compound 7 (6029521)

Compound 4 (click to show)

Compound 4 (click to hide)

Title:

Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase

Reference:

Journal of Medicinal Chemistry 2010 Feb 11;53(3):1329-37

Authors:

Jing-Ping Lu, Sergio C. Chai, Qi-Zhuang Ye

Compounds:

Compound 4 (6025190), Compound 7 (5970049), Compound 8 (7114304)