Bioactive Small Molecules

Compound 1, NB-2

NB-2 (click to show)

NB-2 (click to hide)

Title:

N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion

Reference:

Antimicrobial Agents and Chemotherapy, 2004 Nov;48(11):4349-59

Authors:

Shibo Jiang, Hong Lu, Shuwen Liu, Qian Zhao, Yuxian He, and Asim K. Debnath

Compounds:

NB-2 (5987008), NB-64 (6500658)

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

Reference:

J. Biol. Chem., 2008 Oct 24;283(43):29461-72

Authors:

Roberta Noberinia, Mitchell Koolpe, Satyamaheshwar Peddibhotla, Russell Dahl, Ying Su, Nicholas D. P. Cosford, Gregory P. Roth, and Elena B. Pasquale

Compounds:

Compound 1 (5987008), Compound 2 (5965041)