Bioactive Small Molecules

ethyl 2-anilino-5-(3-hydroxybenzylidene)-4-oxo-4,5-dihydro-3-thiophenecarboxylate

5966451, CFTact-15

5966451 (click to show)
5966451 (click to hide)
Title:
Small-molecule activators of RNase L with broad-spectrum antiviral activity
Reference:
PNAS 2007 Jun 5;104(23):9585-90
Authors:
Chandar S. Thakur, Babal Kant Jha, Beihua Dong, Jaydip Das Gupta, Kenneth M. Silverman, Hongxia Mao, Hiro Sawai, Akiko O. Nakamura, Amiya K. Banerjee, Andrei Gudkov, and Robert H. Silverman
Compounds:
5966451 (5966451), 6645744 (6645744), 7023139 (7023139), 5950331 (5950331), 6474572 (6474572), 5142087 (5142087), 5972155 (5972155), 5973265 (5973265), 5947495 (5947495), 6131864 (6131864), 6131645 (6131645), 6131416 (6131416)
CFTact-15 (click to show)
CFTact-15 (click to hide)
Title:
High-affinity Activators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Conductance Identified by High-throughput Screening
Reference:
The Journal of Biological Chemistry 2002 Oct 4;277(40):37235-41.
Authors:
Tonghui Ma, L. Vetrivel, Hong Yang, Nicoletta Pedemonte, Olga Zegarra-Moran, Luis J. V. Galietta, and A. S. Verkman
Compounds:
CFTact-02 (6042112), CFTact-04 (5738519), CFTact-06 (5972686), CFTact-07 (5936587), CFTact-08 (5773709), CFTact-09 (6043758), CFTact-11 (5101039), CFTact-12 (6142416), CFTact-13 (5218287), CFTact-15 (5966451), CFTact-16 (6143156), CFTact-17 (5312649)