Bioactive Small Molecules

Compound 2, Compound 3

Compound 2 (click to show)

Compound 2 (click to hide)

Title:

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors

Reference:

J. Biol. Chem., 2008 Oct 24;283(43):29461-72

Authors:

Roberta Noberinia, Mitchell Koolpe, Satyamaheshwar Peddibhotla, Russell Dahl, Ying Su, Nicholas D. P. Cosford, Gregory P. Roth, and Elena B. Pasquale

Compounds:

Compound 1 (5987008), Compound 2 (5965041)

Compound 3 (click to show)

Compound 3 (click to hide)

Title:

Identification of small molecule inhibitors of pyruvate kinase M2

Reference:

Biochemical Pharmacology, Volume 79, Issue 8, 15 April 2010, Pages 1118-1124, ISSN 0006-2952, DOI: 10.1016/j.bcp.2009.12.003.

Authors:

Matthew G. Vander Heiden, Heather R. Christofk, Eli Schuman, Alexander O. Subtelny, Hadar Sharfi, Edward E. Harlow, Jun Xian, Lewis C. Cantley

Compounds:

Compound 3 (5965041)