Bioactive Small Molecules

CHEM, Chembridge 5861528, Chembridge-5861528, Compound 104

CHEM (click to show)

CHEM (click to hide)

Title:

Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy

Reference:

Pharmacol Biochem Behav. 2013 Mar;104:90-6

Authors:

Hong Wei, Hanna Viisanen, Diana Amorim, Ari Koivisto, Antti Pertovaara

Compounds:

CHEM (5861528)

CHEM (click to show)

CHEM (click to hide)

Title:

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat

Reference:

Neuropharmacology. 2010 Mar;58(3):578-84. Epub 2009 Dec 29.

Authors:

Hong Wei, Hugh Chapman, Marja Saarnilehto, Katja Kuokkanen, Ari Koivisto, Antti Pertovaara

Compounds:

CHEM (5861528)

CHEM (click to show)

CHEM (click to hide)

Title:

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals.

Reference:

Anesthesiology, 2009 Jul;111(1):147-54

Authors:

H Wei, MM Hamalainen, M Saarnilehto, A Koivisto, and A Pertovaara

Compounds:

CHEM (5861528)

CHEM (click to show)

CHEM (click to hide)

Title:

Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat

Reference:

Pain. 2011 Mar;152(3):582-91.

Authors:

Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A.

Compounds:

CHEM (5861528)

Chembridge-5861528 (click to show)

Chembridge-5861528 (click to hide)

Title:

Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy

Reference:

Scandinavian Journal of Pain. 2013 Jul; 4(3):129-136.

Authors:

Ari Koivisto, Antti Pertovaaraemail

Compounds:

Chembridge-5861528 (5861528)

Compound 104 (click to show)

Compound 104 (click to hide)

Title:

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents

Reference:

Journal of Medicinal Chemistry 2010 Jul 22;53(14):5085-107.

Authors:

Pier Giovanni Baraldi, Delia Preti, Serena Materazzi, Pierangelo Geppetti

Compounds:

Compound 102 (6106799), Compound 104 (5861528)

Chembridge 5861528 (click to show)

Chembridge 5861528 (click to hide)

Title:

(+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice

Reference:

Eur J Pharmacol. 2015 Jun 15;757:53-8. doi: 10.1016/j.ejphar.2015.03.056. Epub 2015 Mar 31.

Authors:

Jun Jiang, Ying Ying Shen, Jun Li, Yu Hui Lin, Chun Xia Luo, Dong Ya Zhu,

Compounds:

Chembridge 5861528 (5861528)

CHEM (click to show)

CHEM (click to hide)

Title:

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

Reference:

Pharmacol Res. 2012 Jan;65(1):149-58. doi: 10.1016/j.phrs.2011.10.006. Epub 2011 Nov 23.

Authors:

Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Akerman KE, Lindstedt K, Pertovaara A

Compounds:

CHEM (5861528)

CHEM (click to show)

CHEM (click to hide)

Title:

Pronociceptive effects of a TRPA1 channel agonist methylglyoxal in healthy control and diabetic animals

Reference:

Poster-abstracts from SASP 2013 - Poster B9

Authors:

Hanna Viisanen, Maria Lasierra , Hong Wei, Ari Koivisto, Karl E. Akerman, Antti Pertovaara

Compounds:

CHEM (5861528)

Chembridge-5861528 (click to show)

Chembridge-5861528 (click to hide)

Title:

TRPA1.

Reference:

Handb Exp Pharmacol. 2014;222:583-630.

Authors:

Zygmunt PM, Högestätt ED.

Compounds:

Chembridge-5861528 (5861528)

Chembridge-5861528 (click to show)

Chembridge-5861528 (click to hide)

Title:

TRPs: modulation by drug-like compounds.

Reference:

Handb Exp Pharmacol. 2014;223:1077-106.

Authors:

Schaefer M.

Compounds:

Chembridge-5861528 (5861528)

Chembridge-5861528 (click to show)

Chembridge-5861528 (click to hide)

Title:

The TRPA1 channel in inflammatory and neuropathic pain and migraine.

Reference:

Rev Physiol Biochem Pharmacol. 2014;167:1-43.

Authors:

Nassini R, Materazzi S, Benemei S, Geppetti P.

Compounds:

Chembridge-5861528 (5861528)

Chembridge-5861528 (click to show)

Chembridge-5861528 (click to hide)

Title:

Antinociceptive effect of hydroalcoholic extract and isoflavone isolated from Polygala molluginifolia in mice: evidence for the involvement of opioid receptors and TRPV1 and TRPA1 channels

Reference:

Authors:

Catharina Nucci-Martins, LeandroF. Nascimento, Dalila Venzke, Lizandra C. Brethanha, AlyssonV.F. Sako, AldoS. Oliveira, InêsM.C. Brighente, Gustavo A. Micke, MoacirG. Pizzolatti,AdairR.S. Santos

Compounds:

Chembridge-5861528 (5861528)