Bioactive Small Molecules

PAC-1

PAC-1 (click to show)

PAC-1 (click to hide)

Title:

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

Reference:

Nat Chem Biol. 2006 Oct;2(10):543-50

Authors:

Karson S Putt, Grace W Chen, Jennifer M Pearson, Joseph S Sandhorst, Martin S Hoagland, Jung-Taek Kwon, Soon-Kyung Hwang, Hua Jin, Mona I Churchwell, Myung-Haing Cho, Daniel R Doerge, William G Helferich & Paul J Hergenrother

Compounds:

PAC-1 (5851625)

PAC-1 (click to show)

PAC-1 (click to hide)

Title:

Small molecules not direct activators of caspases

Reference:

Nat Chem Biol. 2007 Sep;3(9):519; author reply 520.

Authors:

Jean-Bernard Denault, Marcin Drag, Guy S Salvesen, Juliano Alves, Analeah B Heidt, Quinn Deveraux & Jennifer L Harris

Compounds:

PAC-1 (5851625)