Bioactive Small Molecules

1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furyl)methylene]-3,5-pyrazolidinedione

PYZD-4409

PYZD-4409 (click to show)
PYZD-4409 (click to hide)
Title:
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Reference:
Blood. 2010 Mar 18;115(11):2251-9. Epub 2010 Jan 14.
Authors:
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD.
Compounds:
PYZD-4409 (5844409), PYZDmut (5629762)
PYZD-4409 (click to show)
PYZD-4409 (click to hide)
Title:
Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.
Reference:
J Clin Oncol. 2013 Mar 20;31(9):1231-8. doi: 10.1200/JCO.2012.44.0958. Epub 2013 Jan 28.
Authors:
Micel LN, Tentler JJ, Smith PG, Eckhardt GS.
Compounds:
PYZD-4409 (5844409)