Bioactive Small Molecules

SANT-1, SANT1

SANT1 (click to show)

SANT1 (click to hide)

Title:

Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation

Reference:

Cancer Lett. 2013 Jan 28;328(2):297-306.

Authors:

Gerardo Valadez J, Grover VK, Carter MD, Calcutt MW, Abiria SA, Lundberg CJ, Williams TV, Cooper MK.

Compounds:

SAG {Not From ChemBridge}, SANT1 (5786262)

SANT-1 (click to show)

SANT-1 (click to hide)

Title:

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

Reference:

Biochem Pharmacol. 2010 Sep 1;80(5):712-23. Epub 2010 Apr 20.

Authors:

Mas C, Altaba AR.

Compounds:

SANT-1 (5786262), SANT-2 (5800831), SANT-3 (5725940), SANT-4 (5568598), TC-132 {Not in our database}

SANT-1 (click to show)

SANT-1 (click to hide)

Title:

Small molecule modulation of Smoothened activity

Reference:

PNAS October 29, 2002 vol. 99 no. 22 14071-14076

Authors:

James K. Chen, Jussi Taipale, Keith E. Young, Tapan Maiti, and Philip A. Beachy

Compounds:

SANT-1 (5786262), SANT-2 (5800831), SANT-3 (5725940), SANT-4 (5568598)

SANT-1 (click to show)

SANT-1 (click to hide)

Title:

Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.

Reference:

Mol Pharmacol. 2013 May;83(5):1020-9. doi: 10.1124/mol.112.084590.

Authors:

Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A, Manetti F, Solinas A, Petricci E, Taddei M, Ruat M.

Compounds:

SANT-1 (5786262)

SANT-1 (click to show)

SANT-1 (click to hide)

Title:

Small molecule modulation of Smoothened activity

Reference:

PNAS 2002 Oct 29;99(22):14071-6.

Authors:

Chen JK, Taipale J, Young KE, Maiti T, Beachy PA.

Compounds:

SANT-1 (5786262), SANT-2 (5800831), SANT-3 (5725940), SANT-4 (5568598)