Bioactive Small Molecules

RTC#13, RTC13

RTC#13 (click to show)

RTC#13 (click to hide)

Title:

Nonaminoglycoside compounds induce readthrough of nonsense mutations

Reference:

Journal of Experimental Medicine 2009 Sep 28;206(10):2285-97. Epub 2009 Sep 21.

Authors:

Du L, Damoiseaux R, Nahas S, Gao K, Hu H, Pollard JM, Goldstine J, Jung ME, Henning SM, Bertoni C, Gatti RA

Compounds:

RTC13 (5735019), RTC14 (5311257), RTC#13 (5735019), RTC#14 (5311257)

RTC#13 (click to show)

RTC#13 (click to hide)

Title:

Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy

Reference:

Hum Mol Genet. 2012 Sep 15;21(18):4007-20

Authors:

Kayali R, Ku JM, Khitrov G, Jung ME, Prikhodko O, Bertoni C

Compounds:

RTC13 (5735019), RTC14 (5311257), RTC#13 (5735019), RTC#14 (5311257)