Bioactive Small Molecules

3a, Compound 4a

3a (click to show)

3a (click to hide)

Title:

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

Reference:

Mol Cancer Ther 2009 Jun;8(6):1473-83

Authors:

Zanna Beharry, Marina Zemskova, Sandeep Mahajan, Fengxue Zhang, Jian Ma, Zuping Xia, Michael Lilly, Charles D. Smith, and Andrew S. Kraft

Compounds:

1a (5377712), 3a (5721666), 10a (5377792), 18a (5378142), 20a (5265182), 21a (5376968), 23a (5260028), 24a (5363403)

Compound 4a (click to show)

Compound 4a (click to hide)

Title:

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

Reference:

J. Med. Chem., 2009 Jan 8;52(1):74-86

Authors:

Zuping Xia, Christian Knaak, Jian Ma, Zanna M. Beharry, Campbell McInnes, Wenxue Wang, Andrew S. Kraft and Charles D. Smith

Compounds:

Compound 4a (5721666), Compound F7 (7642857), 5378227 (5378227), Compound H4 (7644127)