Bioactive Small Molecules

12, LOX-1, LOXBlock-1

LOXBlock-1 (click to show)

LOXBlock-1 (click to hide)

Title:

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling

Reference:

FASEB J. 2013 Feb;27(2):437-45. Epub 2012 Oct 15.

Authors:

Anton Pekcec, Kazim Yigitkanli, Joo Eun Jung, Stefanie Pallast, Changhong Xing, Alexander Antipenko, Maria Minchenko, Dimitar B. Nikolov, Theodore R. Holman, Eng H. Lo, and Klaus van Leyen.

Compounds:

LOXBlock-1 (5680672)

LOXBlock-1 (click to show)

LOXBlock-1 (click to hide)

Title:

Novel Lipoxygenase Inhibitors as Neuroprotective Reagents

Reference:

Journal of Neuroscienc Research, 2008 Mar;86(4):904-9

Authors:

Klaus van Leyen, Ken Arai, Guang Jin, Victor Kenyon, Bettina Gerstner, Paul A. Rosenberg, Theodore R. Holman, and Eng H. Lo

Compounds:

LOXBlock-1 (5680672), LOXBlock-2 (6635967), LOXBlock-3 (6640337)

12 (click to show)

12 (click to hide)

Title:

Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models

Reference:

J. Med. Chem., 2006 Feb 23;49(4):1356-63

Authors:

Victor Kenyon, Ilya Chorny, Wendy J. Carvajal, Theodore R. Holman, and Matthew P. Jacobson

Compounds:

15 (6635967), 12 (5680672), 9 (6640337)

LOX-1 (click to show)

LOX-1 (click to hide)

Title:

Akt and mTOR mediate programmed necrosis in neurons.

Reference:

Cell Death Dis. 2014 Feb 27;5:e1084.

Authors:

Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ.

Compounds:

LOX-1 (5680672)