Bioactive Small Molecules

CID-2858522, Compound 1, Compound 1a

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Selective benzimidazole inhibitors of the antigen receptor-mediated NF-kappaB activation pathway

Reference:

Bioorg Med Chem. 2010 Mar 1;18(5):1918-24. Epub 2010 Jan 25.

Authors:

Karl J. Okolotowicz, Ranxin Shi, Xueying Zheng, Mary MacDonald, John C. Reed, John R. Cashman

Compounds:

Compound 1 (5653914)

CID-2858522 (click to show)

CID-2858522 (click to hide)

Title:

Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-kappaB Activation Induced by Protein Kinase C

Reference:

ACS Chemical Biology 2010 Mar 19;5(3):287-99

Authors:

Ranxin Shi, Daniel Re, Eric Dudl, Michael Cuddy, Karl J Okolotowicz, Russell Dahl, Ying Su, Andrew Hurder, Shinichi Kitada, Satyamaheshwar Peddibhotla, Gregory P. Roth, Layton H. Smith, Thomas J. Kipps, Nicholas Cosford, John Cashman, John C. Reed

Compounds:

CID-2858522 (5653914)

Compound 1a (click to show)

Compound 1a (click to hide)

Title:

Inhibition of Protein Kinase C-Driven Nuclear Factor-KappaB Activation: Synthesis, Structure-Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules

Reference:

Journal of Medicinal Chemistry 2010 53 (12), 4793-4797

Authors:

Satyamaheshwar Peddibhotla, Ranxin Shi, Pasha Khan, Layton H. Smith, Arianna Mangravita-Novo, Michael Vicchiarelli, Ying Su, Karl J. Okolotowicz, John R. Cashman, John C. Reed, Gregory P. Roth

Compounds:

Compound 1a (5653914), Compound 2 (6220207), Compound 3 (5656325), Compound 1o {Not in our database}, Compound 1p {Not in our database}