Bioactive Small Molecules

4-(2-furylmethylene)-1-(4-methylphenyl)-3,5-pyrazolidinedione

PYZDmut

PYZDmut (click to show)
PYZDmut (click to hide)
Title:
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Reference:
Blood. 2010 Mar 18;115(11):2251-9. Epub 2010 Jan 14.
Authors:
Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, Rose D, Moffat J, Batey RA, Dhe-Paganon S, Schimmer AD.
Compounds:
PYZD-4409 (5844409), PYZDmut (5629762)