Bioactive Small Molecules

Nemadipine, Nemadipine-A

Nemadipine-A (click to show)

Nemadipine-A (click to hide)

Title:

A small-molecule screen in C. elegans yields a new calcium channel antagonist

Reference:

Nature 2006 May 4;441(7089):91-5.

Authors:

Trevor C. Y. Kwok, Nicole Ricker, Regina Fraser, Allen W. Chan, Andrew Burns, Elise F. Stanley, Peter McCourt, Sean R. Cutler & Peter J. Roy

Compounds:

Nemadipine-A (5619779)

Nemadipine (click to show)

Nemadipine (click to hide)

Title:

Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs

Reference:

European Journal of Pharmacology, 2009 Jan 14;602(2-3):255-61. Epub 2008 Dec 3.

Authors:

Kwokyin Hui, Trevor C.Y. Kwok, Wojciech Kostelecki, Jessica Leen, Peter John Roy, Zhong-Ping Feng

Compounds:

Nemadipine (5619779)

Nemadipine (click to show)

Nemadipine (click to hide)

Title:

A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels

Reference:

PLoS Genet 2008 May 9;4(5)

Authors:

Kwok, Trevor C. Y. ; Hui, Kwokyin ; Kostelecki, Wojciech ; Ricker, Nicole ; Selman, Guillermo ; Feng, Zhong-Ping ; Roy, Peter John

Compounds:

Nemadipine (5619779)