Bioactive Small Molecules

benzyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

TGR5 agonist

TGR5 agonist (click to show)
TGR5 agonist (click to hide)
Title:
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Reference:
Nature 2006 Jan 26;439(7075):484-9
Authors:
Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, Marcelo A. Christoffolete, Brian W. Kim, Hiroyuki Sato, Nadia Messaddeq, John W. Harney, Osamu Ezaki, Tatsuhiko Kodama, Kristina Schoonjans, Antonio C. Bianco & Johan Auwerx
Compounds:
TGR5 agonist (5569653)