Bioactive Small Molecules

2,3-DCPE

2,3-DCPE (click to show)

2,3-DCPE (click to hide)

Title:

Induction of Apoptosis and Down-Regulation of Bcl-XL in Cancer Cells by a Novel Small Molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol

Reference:

Cancer Research 2004 Feb 1;64(3):1110-3

Authors:

Shuhong Wu, Hongbo Zhu, Jian Gu, Lidong Zhang, Fuminori Teraishi, John J. Davis, Dietmar A. Jacob and Bingliang Fang

Compounds:

2,3-DCPE (5568781), 3,4-DCPE (7018363), 2,6-DCEE {No in our database}

2,3-DCPE (click to show)

2,3-DCPE (click to hide)

Title:

Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK

Reference:

Oncogene 2004 Jun 24;23(29):4984-92

Authors:

Hongbo Zhu, Lidong Zhang, Shuhong Wu, Fuminori Teraishi, John J Davis, Dietmar Jacob and Bingliang Fang

Compounds:

2,3-DCPE (5568781), 2,3-DCEE {Structure not provided in article}

2,3-DCPE (click to show)

2,3-DCPE (click to hide)

Title:

Anticancer and chemosensitizing effects of 2,3-DCPE in ovarian carcinoma cell lines: Link with ERK activation and modulation of p21WAF1/CIP1, Bcl-2 and Bcl-xL expression

Reference:

Gynecol Oncol. 2007 May;105(2):373-84.

Authors:

Villedieu, M.;Briand, M.;Duval, M.;Heron, J.F.;Gauduchon, P.;Poulain, L.;

Compounds:

2,3-DCPE (5568781)