Bioactive Small Molecules

13, PIT-1

PIT-1 (click to show)

PIT-1 (click to hide)

Title:

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

Reference:

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20126-31. Epub 2010 Nov 1.

Authors:

Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A.

Compounds:

PIT-1 (5535396), DM-PIT-1 (7797459), PIT-1i-1 {not in our database}, PIT-1i-2 {not in our database}

13 (click to show)

13 (click to hide)

Title:

Targeting Tn5 Transposase Identifies Human Immunodeficiency Virus Type 1 Inhibitors

Reference:

Antimicrobial agents and Chemotherapy, 2005 May;49(5):2035-43.

Authors:

Brandon Ason, Daniel J. Knauss, Allison M. Balke, George Merkel, Anna Marie Skalka, and William S. Reznikoff

Compounds:

1 (6160027), 2 (6141194), 3 (6140731), 4 (6158572), 5 (5868253), 6 (6075259), 7 (5980789), 8 (6058083), 9 (6229546), 10 (6176494), 11 (6192779), 12 (5546355), 13 (5535396), 14 (6227564), 15 (5233170), 16 (5232986), 17 (5232985), 18 (6046791), 19 (6044999), 20 (5988232), 10-A (5789176), 10-B (6204337), 10-C (6206397), 10-D (8065508), 10-E (6171674), 10-F (6180772), 10-G (6215673)