Bioactive Small Molecules

125B11, Fatostatin

125B11 (click to show)

125B11 (click to hide)

Title:

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Reference:

Cancer Res. 2013 May 1;73(9):2850-62.

Authors:

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Ben

Compounds:

125B11 (5533803), fatostatin (5533803)

Fatostatin (click to show)

Fatostatin (click to hide)

Title:

SREBP-1 activation by glucose mediates TGF-beta upregulation in mesangial cells

Reference:

Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F329-41. Epub 2011 Oct 26.

Authors:

Uttarwar L, Gao B, Ingram AJ, Krepinsky JC.

Compounds:

Fatostatin (5533803)

125B11 (click to show)

125B11 (click to hide)

Title:

Identification of bioactive molecules by adipogenesis profiling of organic compounds

Reference:

J Biol Chem. 2003 Feb 28;278(9):7320-4. Epub 2002 Dec 19.

Authors:

Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M.

Compounds:

Fatostatin (5533803), 125B11 (5533803), 69A10 (5231609), 92D8 (5379589), 18F9 (5682321), 99D5 (5314016), 124D8 (5527173), 91E2 (5380817), 26E6 (5263799), 19B8 (5669313), 94G6 (5398003)

Fatostatin (click to show)

Fatostatin (click to hide)

Title:

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP

Reference:

Chem Biol. 2009 Aug 28;16(8):882-92.

Authors:

Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M.

Compounds:

Fatostatin (5533803)