Bioactive Small Molecules

4-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-(1H-pyrazol-1-yl)pyrimidine

Compound 5

Compound 5 (click to show)
Compound 5 (click to hide)
Title:
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
Reference:
J Med Chem. 2015 Aug 27;58(16):6653-64. Epub 2015 Aug 12.
Authors:
Christopher JA, Aves SJ, Bennett KA, Dore AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M.
Compounds:
Compound 5 (55113728)