Bioactive Small Molecules

AX-000

AX-000 (click to show)

AX-000 (click to hide)

Title:

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

Reference:

Sci Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.

Authors:

Borroto A, Reyes-Garau D, Jimenez MA, Carrasco E, Moreno B, Martinez-Pasamar S, Cortes JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J, Heidarieh H, Rueda J, Esteve P, Cibrian D, Martinez-Riano A, Mendoza P, Prieto C, Calleja E, Oeste CL, Orfao A, Fresno M, Sanchez-Madrid F, Alcami A, Bovolenta P, Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon

Compounds:

AX-000 (5231365), AX-024 {Synthesized by authors}