Bioactive Small Molecules

Mepazine, Mepazine acetate

Mepazine (click to show)

Mepazine (click to hide)

Title:

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL

Reference:

Cancer Cell. 2012 Dec 11;22(6):825-37

Authors:

Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, Peter von Kries J, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ, Krappmann D.

Compounds:

Mepazine (5216177)

Mepazine acetate (click to show)

Mepazine acetate (click to hide)

Title:

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Reference:

J Neuroinflammation. 2014 Jul 21;11:124. doi: 10.1186/1742-2094-11-124.

Authors:

Mc Guire C, Elton L, Wieghofer P, Staal J, Voet S, Demeyer A, Nagel D, Krappmann D, Prinz M, Beyaert R, van Loo G

Compounds:

Mepazine acetate (5216177)

Mepazine (click to show)

Mepazine (click to hide)

Title:

The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling

Reference:

J Cell Sci. 2016 May 1;129(9):1775-80. doi: 10.1242/jcs.185025. Epub 2016 Mar 22.

Authors:

Douanne T, Gavard J, Bidère N

Compounds:

Mepazine (5216177)