Bioactive Small Molecules

Compound 14, Compound 15

Compound 15 (click to show)

Compound 15 (click to hide)

Title:

Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant

Reference:

Chemistry & Biology, Volume 17, Issue 1, 29 January 2010, Pages 46-56

Authors:

Nicolas Basse, Joel L. Kaar, Giovanni Settanni, Andreas C. Joerger, Trevor J. Rutherford, Alan R. Fersht

Compounds:

Compound 2 {Not in our database}, Compound 4 (7494872), Compound 11 (5523237), Compound 15 (5213898)

Compound 14 (click to show)

Compound 14 (click to hide)

Title:

Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

Reference:

J Med Chem. 2015 Feb 12;58(3):1205-14. Epub 2015 Jan 16.

Authors:

Devine SM, Mulcair MD, Debono CO, Leung EW, Nissink JW, Lim SS, Chandrashekaran IR, Vazirani M, Mohanty B, Simpson JS, Baell JB, Scammells PJ, Norton RS, Scanlon MJ

Compounds:

Compound 1 (5121788), Compound 5 (5545521), Compound 6 (5341866), Compound 14 (5213898)