Bioactive Small Molecules

4EGI-1

4EGI-1 (click to show)

4EGI-1 (click to hide)

Title:

Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G

Reference:

Cell, 2007 Jan 26;128(2):257-67.

Authors:

Nathan J. Moerke, Huseyin Aktas, Han Chen, Sonia Cantel, Mikhail Y. Reibarkh, Amr Fahmy, John D. Gross, Alexei Degterev, Junying Yuan, Michael Chorev, Jose A. Halperin, and Gerhard Wagner,

Compounds:

4EGI-1 (5154300)

4EGI-1 (click to show)

4EGI-1 (click to hide)

Title:

Inhibition of oncogenic cap-dependent translation by 4EGI-1 reduces growth, enhances chemosensitivity and alters genome-wide translation in non-small cell lung cancer

Reference:

Cancer Gene Ther. 2018 Nov 12. doi: 10.1038/s41417-018-0058-6. [Epub ahead of print]

Authors:

De A, Jacobson BA, Peterson MS, Stelzner ME, Jay-Dixon J, Kratzke MG, Patel MR, Bitterman PB, Kratzke RA.

Compounds:

4EGI-1 (5154300)