Bioactive Small Molecules

Salubrinal

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1*

Reference:

J. Biol. Chem., 2009 Jan 16;284(3):1593-603.

Authors:

Kim I, Shu CW, Xu W, Shiau CW, Grant D, Vasile S, Cosford ND, Reed JC.

Compounds:

Salubrinal (5147990), CID-2891837 (6239507), CID-2879344 (5976228)

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

Reference:

Science. 2005 Feb 11;307(5711):935-9.

Authors:

Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J.

Compounds:

Salubrinal (5147990)

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Reference:

American Journal of Pathology. 2008 Aug;173(2):451-62

Authors:

Hong-wa Yung, Stefania Calabrese, Debby Hynx, Brian A. Hemmings, Irene Cetin, D. Stephen Charnock-Jones and Graham J. Burton

Compounds:

Salubrinal (5147990)

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

Reference:

Cell Death and Differentiation 2008 Mar;15(3):589-99.

Authors:

M Boyce, B F Py, A G Ryazanov, J S Minden, K Long, D Ma and J Yuan

Compounds:

Salubrinal (5147990)

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 GTP Met-tRNAi Met Ternary Complex Availability

Reference:

Molecular Biology of the Cell 2006 Nov;17(11):4632-44

Authors:

Francis Robert, Lee D. Kapp, Shakila N. Khan, Michael G. Acker, Sarah Kolitz, Shirin Kazemi, Randal J. Kaufman, William C. Merrick, Antonis E. Koromilas, Jon R. Lorsch, and Jerry Pelletier

Compounds:

Salubrinal (5147990), Sal003 (5143134), NSC119889 {not in our databases}, NSC119893 {not in our databases}, ATA {not in our databases}

Salubrinal (click to show)

Salubrinal (click to hide)

Title:

ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells

Reference:

Virology. 2008 Sep 30;379(2):197-204

Authors:

Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM.

Compounds:

Salubrinal (5147990)