Bioactive Small Molecules

2-phenylacetylenesulfonamide

PAS, PES, Pifithrin-mu

Pifithrin-mu (click to hide)

Title:: Small Molecule Inhibitor of p53 Binding to Mitochondria Protects Mice from Gamma Radiation
Reference:: Nature Chemical Biology 2006 Sep;2(9):474-9. Epub 2006 Jul 23.
Authors:: E Strom, S Sathe, P Komarov, O Chernova, I Pavlovska, I Shyshynova, D Bosykh, L Burdelya, R Macklis, R Skaliter, E Komarova and A Gudkov
Compounds:: Pifithrin-mu (5147472)

PAS (click to hide)

Title:: 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
Reference:: Blood. 2009 Aug 6;114(6):1217-25. Epub 2009 Jun 10.
Authors:: Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C.
Compounds:: Pifithrin-mu (5147472), PAS (5147472)

PES (click to hide)

Title:: A Small Molecule Inhibitor of Inducible Heat Shock Protein 70
Reference:: Molecular Cell, 2009 Oct 9;36(1):15-27. doi: 10.1016/j.molcel.2009.09.023.
Authors:: J. I-Ju Leu, Julia Pimkina, Amanda Frank, Maureen E. Murphy, Donna L. George
Compounds:: PES (5147472)