Bioactive Small Molecules

Pirl-1, Pirl1

Pirl-1 (click to show)

Pirl-1 (click to hide)

Title:

Biochemical suppression of small molecule inhibitors: a new strategy to identify inhibitor targets and signaling pathway components

Reference:

Chem Biol. 2006 April; 13(4): 443-452.

Authors:

Jeffrey R. Peterson, Andres M. Lebensohn, Henry E. Pelish, and Marc W. Kirschner

Compounds:

Pirl-1 (5137877), Compound 1 (5256947), Related Compound 1 (6047648), Related Compound 2 (6044866), Related Compound 3 {Not in our database}, Related Compound 4 {Not in our database}, Related Compound 5 (5169178), Related Compound 7 (5133292)

Pirl-1 (click to show)

Pirl-1 (click to hide)

Title:

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis

Reference:

Am J Physiol Gastrointest Liver Physiol 296: G78-G92, 2009

Authors:

Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O.

Compounds:

Pirl-1 (5137877)

Pirl-1 (click to show)

Pirl-1 (click to hide)

Title:

The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells

Reference:

Bioochemical pharmacology 71 (2006) 1720-1726

Authors:

Henry E. Pelish, William Ciesla, Nori Tanaka, Krishna Reddy, Matthew D. Shair, Tomas Kirchhausen, Wayne I. Lencer

Compounds:

Pirl-1 (5137877), Pirl1 (5137877)