Bioactive Small Molecules

Compound 17, NPPD

NPPD (click to show)

NPPD (click to hide)

Title:

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

Reference:

Biol. Cell, 2006 Sep;98(9):511-22.

Authors:

Anne Blangy, Nathalie Bouquier, Cecile Gauthier-Rouviere, Susanne Schmidt, Anne Debant, Jean-Paul Leonetti & Philippe Fort

Compounds:

NPPD (5133201), PEPD (5215341), CPEPD (5633007)

NPPD (click to show)

NPPD (click to hide)

Title:

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

Reference:

Chemistry & Biology, 2009 Jun 26;16(6):657-66.

Authors:

Nathalie Bouquier, Emmanuel Vignal, Sophie Charrasse, Mylene Weill, Susanne Schmidt, Jean-Paul Leonetti, Anne Blangy, Philippe Fort

Compounds:

ITX1 (6170085), NPPD (5133201), ITX3 (6007262)

Compound 17 (click to show)

Compound 17 (click to hide)

Title:

Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.

Reference:

ACS Chem Biol. 2014 Oct 17;9(10):2393-403. Epub 2014 Aug 15.

Authors:

Mukherjee S, Weiner WS, Schroeder CE, Simpson DS, Hanson AM, Sweeney NL, Marvin RK, Ndjomou J, Kolli R, Isailovic D, Schoenen FJ, Frick DN.

Compounds:

Compound 18 (6238046), Compound 16 (6239307), Compound 17 (5133201)