Bioactive
Small Molecules
Nec-1, Necrostatin-1
Nec-1 (click to show)
Nec-1 (click to hide)
Title:
Structure activity relationship study of novel necroptosis inhibitors
Reference:
Bioorganic and Medicinal Chemistry Letters 15 (2005) 5039�5044
Authors:
Xin Teng, Alexei Degterev, Prakash Jagtap, Xuechao Xing, Sungwoon Choi, Regine Denu, Junying Yuan and Gregory D. Cuny
Compounds:
Necrostatin-1 (
5115807
), Nec-1 (
5115807
)
Nec-1 (click to show)
Nec-1 (click to hide)
Title:
Necrostatin: a potentially novel cardioprotective agent?
Reference:
Cardiovasc Drugs Ther. 2007 Aug;21(4):227-33
Authors:
Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM
Compounds:
Necrostatin-1 (
5115807
), Nec-1 (
5115807
), Necrostatin-1i {not in our database}, Nec-1i {not in our database}
Nec-1 (click to show)
Nec-1 (click to hide)
Title:
Chemical genetic approaches to probing cell death
Reference:
Curr Opin Chem Biol. 2007 Feb;11(1):83-7
Authors:
Gangadhar NM, Stockwell BR
Compounds:
Necrostatin-1 (
5115807
), Nec-1 (
5115807
), Aprotoxin A {not in our database}, Erastin {not in our database}
Necrostatin-1 (click to show)
Necrostatin-1 (click to hide)
Title:
Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells
Reference:
J Neurochem. 2007 Dec;103(5):2004-14
Authors:
Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC, Chua BH.
Compounds:
Necrostatin-1 (
5115807
)
Nec-1 (click to show)
Nec-1 (click to hide)
Title:
Chemical Inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Reference:
Nat Chem Biol. 2005 Jul;1(2):112-9
Authors:
A Degterev, Z Huang, M Boyce, Y Li, P Jagtap, N Mizushima, G Cuny, T Mitchison, MA Moskowitz and J Yuan
Compounds:
Necrostatin-1 (
5115807
), Nec-1 (
5115807
)