Bioactive Small Molecules

Vacuolin-1

Vacuolin-1 (click to show)

Vacuolin-1 (click to hide)

Title:

The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing

Reference:

EMBO Rep. 2004 Sep;5(9):883-8.

Authors:

Jan Cerny , Yan Feng, Anan Yu, Katsuya Miyake, Barbara Borgonovo, Judith Klumperman, Jacopo Meldolesi , Paul L. McNeil & Tomas Kirchhausen

Compounds:

Vacuolin-1 (5114069)

Vacuolin-1 (click to show)

Vacuolin-1 (click to hide)

Title:

The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis

Reference:

EMBO Reports 2005 Sep;6(9):843-7.

Authors:

Chau Huynh & Norma W. Andrews

Compounds:

Vacuolin-1 (5114069)

Vacuolin-1 (click to show)

Vacuolin-1 (click to hide)

Title:

Control of Parasitophorous Vacuole Expansion by LYST/Beige Restricts the Intracellular Growth of Leishmania amazonensis

Reference:

PLoS Pathog. 2008 Oct;4(10):e1000179. Epub 2008 Oct 17.

Authors:

Wilson J, Huynh C, Kennedy KA, Ward DM, Kaplan J, Aderem A, Andrews NW.

Compounds:

Vacuolin-1 (5114069)