Bioactive Small Molecules

C1, Compound 1, Compound 2, INP0007

Compound 2 (click to show)

Compound 2 (click to hide)

Title:

Targeting Bacterial Virulence: Inhibitors of Type III Secretion in Yersinia

Reference:

Chemistry & Biology, 10 (March 2003) 241-249.

Authors:

Anna M. Kauppi, Roland Nordfelth, Hanna Uvell, Hans Wolf-Watz and Mikael Elofsson

Compounds:

Compound 1 (5213291), Compound 2 (5113023), Compound 3 {Not in our database}, Compound 4 (5175374)

INP0007 (click to show)

INP0007 (click to hide)

Title:

Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors

Reference:

Antimicrob Agents Chemother. 2007 Jul;51(7):2631-5.

Authors:

Debra L. Hudson, Abigail N. Layton, Terry R. Field, Alison J. Bowen, Hans Wolf-Watz, Mikael Elofsson, Mark P. Stevens, and Edouard E. Galyov

Compounds:

INP0007 (5113023), INP0403 {Not in our database}

INP0007 (click to show)

INP0007 (click to hide)

Title:

Targeting Type III Secretion in Yersinia pestis

Reference:

Antimicrob. Agents Chemother. 2009 Feb;53(2):385-92

Authors:

Ning J. Pan, Michael J. Brady, John M. Leong, and Jon D. Goguen

Compounds:

INP0007 (5113023), Compound 4 (6813327)

C1 (click to show)

C1 (click to hide)

Title:

Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds

Reference:

Cell Host Microbe. 2008 Aug 14;4(2):159-69

Authors:

Kumar Y, Valdivia RH

Compounds:

C1 (5113023)

Compound 1 (click to show)

Compound 1 (click to hide)

Title:

Small molecule inhibitors specifically targeting type III secretion

Reference:

Infec. Immun. 2005 May;73(5):3104-14.

Authors:

Nordfelth R, Kauppi AM, Norberg HA, Wolf-Watz H, Elofsson M.

Compounds:

Compound 1 (5113023)

C1 (click to show)

C1 (click to hide)

Title:

Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle

Reference:

Mol Microbiol. 2006 Sep;61(6):1543-55.

Authors:

K. Wolf, H. J. Betts, B. Chellas-Gery, S. Hower, C. N. Linton, and K. A. Fields

Compounds:

C1 (5113023)

INP0007 (click to show)

INP0007 (click to hide)

Title:

Role for chlamydial type III secretion apparatus in host cytokine expression

Reference:

Infection and Immunity, January 2009, p. 76-84, Vol. 77, No. 1

Authors:

Prantner D, Nagarajan UM.

Compounds:

INP0007 (5113023)

C1 (click to show)

C1 (click to hide)

Title:

Pmp-Like Proteins Pls1 and Pls2 Are Secreted into the Lumen of the Chlamydia trachomatis Inclusion

Reference:

Infection and Immunity, 2008 Sep;76(9):3940-50

Authors:

Ine Jorgensen and Raphael H. Valdivia

Compounds:

C1 (5113023)